A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
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چکیده
منابع مشابه
A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
BACKGROUND The stiff person syndrome (SPS) is a rare and debilitating autoimmune disorder with an unknown pathogenesis and variable clinical presentation that can present a diagnostic challenge. Although entities that clinically mimic stiff-person spectrum disorders (SPSD) have manifested in horses, they have not been reported in dogs. CASE PRESENTATION We describe a 2-year-old beagle dog pre...
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We herein report the case of a 53-year-old man with cerebellar ataxia with anti-glutamic acid decarboxylase antibody (GAD-Ab) who mimicked Miller Fisher syndrome (MFS). He developed ophthalmoplegia, diplopia, and gait ataxia for one week. The serum and cerebrospinal fluid GAD-Ab titers were greatly increased, and the GAD-Ab index suggesting intrathecal antibody synthesis was elevated, while GQ1...
متن کاملAntibodies to 125I-glutamic acid decarboxylase in patients with stiff man syndrome.
Antibodies to glutamic acid decarboxylase (GAD) are found in about 40% of patients with stiff man syndrome. A new assay involving immunoprecipitation of (125)I-glutamic acid decarboxylase was used to measure anti-GAD antibodies in 18 patients with stiff man syndrome. Of the eight serum samples from patients with stiff man syndrome, that had previously been found positive by immunoprecipitation ...
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Antibodies directed against the enzyme glutamic acid decarboxylase (GAD) are believed to be the main cause of destruction of pancreatic islet cells in type I (insulin dependent) diabetes mellitus. The enzyme was found both in the brain and pancreatic beta cells. Although similarities in identity of GAD in human and rat brain have been demonstrated, little is known about the interaction betw...
متن کاملExperience with immunotherapy in 3 patients with cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies.
La asociación con niveles altos de anticuerpos contra la enzima carboxilasa del ácido glutámico (anti-GAD) es bien conocida en el síndrome de la persona rígida o Stiff person syndrome (SPS) y, más recientemente, también se han descrito en un subgrupo de pacientes con ataxia cerebelosa1,2. Sobre la base del probable origen autoinmune de estos síndromes se han ensayado distintas terapias inmunomo...
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ژورنال
عنوان ژورنال: Journal of Clinical Movement Disorders
سال: 2017
ISSN: 2054-7072
DOI: 10.1186/s40734-017-0053-3